Author(s): G. Rajeswari1 , M. Murugan2 and V.R. Mohan2
Objective: In the present study anti-inflammatory activity of ethanol extract of leaf and bark of Hugonia mystax were inveatigated. Methods: The anti-inflammatory activity of ethanol extracts leaf and bark of H. mystax were evaluated by carrageenan induced rat paw edema to determine its effect on chronic phase of inflammation models in rats. Results: Preliminary phytochemical analysis of ethanol extracts of leaf and bark showed the presence of alkaloid, catechin, coumarin, flavonoid, tannin, saponin, steroid, phenol, glycoside, terpenoid and xanthoprotein. Maximum inhibition (83.91%) was obtained at the dose of 500 mg kg -1 of H. mystax leaf after 3 hours of drug treatment in carrageenan induced paw edema, whereas, indomethocin produced 84.82% of inhibition. Conclusion: The present study suggests that H. mystax leaf and bark extrats possess strong antiinflammatory property so it has immense scope as an effective source to develop drug for the treatment of inflammatory related diseases.