DESIGN AND DEVELOPMENT OF CONVENTIONAL TABLETS OF HYDROCHLOROTHIAZIDE AND PROPRANOLOL HYDROCHLORIDE CO-CRYSTALS
Abstract

Author(s): Madhavi U. Bhandwalkar, Omkar S. Bhandwalkar, Pallavi S. Dhekale, Dhairyasheel M. Ghadge, Ujwala K. Jamdade

Hydrochlorothiazide (HCT) is a class IV drug which has limited solubility and permeability, for overcome this problems co-crystallization method is used. Co-crystallization is the process to enhance the physical properties of drug molecule especially the solubility. HCT belongs to diuretic category and Propranolol Hydrochloride (PPL) belongs to Beta blocker category they are combined for use in tablet formulation. Co-crystallization was used to combine two drugs in single solid phase and thus to achieve new approach for combination therapy. Using the new approach co-crystals of PPL with HCT were prepared. Co-crystallization of two drugs were carried out by using solvent evaporation and solution co-crystallization method. The saturation solubility was done to evaluate the solubility of co-crystals. Dissolution properties were determined and compared with the marketed tablet formulation. The prepared co-crystals has shown several times faster release than marketed tablet and optimized co-crystals were characterized by using DSC, FTIR and SEM.

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