Author(s): Mathew George*, Lincy Joseph, Ashitha.K.S
To study the effect of ethanol: acetone extract of Hypericum hircinum have antidepressant activity on Wistar albino rat. Methods: Whole plant was collected and extracted using ethanol: ac etone by maceration. The crude extracts were screened for the biological activity through the assay behavioral study. Antidepressant activity evaluated by using behavioral methods such as ketamine induced sleep, tail suspension method. Result: Hydro alcoholic extract of have significant antidepressant effect on rat. Conclusion: The result indicates that whole plant hydroalcoholic extract was an antidepressant agent. Key words: Antidepressant activity, Hypericum hircinum, rat.