Author(s): Mardia T. El-Sayed*, Kazem Mahmoud, Khadiga M. Ahmed, Hassan M. Awad , and Andreas Hilgeroth
Our novel tetraindoles 1 and 3 that are produced from the acid catalyzed condensation reaction of indoles with aliphatic or aromatic dialdehydes. These tetraindoles have previously synthesized for the first time and published by our group. Tetraindoles 1, 3 and 5 acts as a good precursor for oxidation or dehydration reactions as well as the well known diindolylmethane afforded the first oxidized tetraindoles 2, 4 and 6 with good yield. The antimicrobial activity indicated that the tested compounds (aromatic benzene ring between the tetraindole unit ) showed inhibitory activities with different degree against all tested pathogenic microorganisms including B. subtilits, E. coli, C. albicans and Aspergillus niger. Keywords: Acid catalyzed condensation reaction, Tetraindoles, Oxidation reaction.