Journal of Harmonized Research in Pharmacy

TO STUDY THE IN VITRO EFFECT OF SOME ALCOHOL CONTAINING VOLATILE OILS AS THE SKIN PENETRATION ENHANCERS OF CURCUMIN

Abstract

Author(s): Ganju Kuldeep, Ganju Eisha

The effect of geraniol, linalool and nerol on the skin permeation of curcumin was investigated. The mechanism of skin permeation enhancement of curcumin by essential oils treatment was evaluated by Activation energy measurement. The effectiveness of the oils as the penetration enhancers was found to be in the following descending order: geraniol>linalool>nerol. The results of thermodynamic studies and of geraniol incorporated group suggested additional mechanisms for geraniol facilitated permeation. To conclude geraniol has been diagnosed to be thebest penetration enhancer of all others to allow curcumin pass through the skin epidermis. Keywords: Geraniol, linalool, nerol, TDDS