Author(s): Sandeep Kumar Jaiswal, D. N. Jhade, Sunil Kumar Shah, Chandra Kishor Tyagi
The aim of the present study was to prepare and evaluate microporous pellets loaded with Indomethacin is an oral Non-steroidal anti-inflammatory drug, indicated for the treatment of rheumatoid art hritis. Indomethacin is indicated for the treatment of rheumatoid arthritis, alone or in combination with other NSAID’S drugs. Indomethacin is also indicated for the treatment of ankylosing, spondylitis, osteoarthritis. The frequent adverse effects of NSAIDs like Indomethacin are gastro-intestinal disturbances. Enteric coated formulations minimize these symptoms. Multi-particulate system such as porous pellets disperse freely in the gastro-intestinal tract, contributes to maximum drug absorption, reduced peak plasma fluctuations and have less side effects. Porous pellets were prepared by extrusion /spheronization method. Keywords: Indomethacin Pellets, Controlled release, Extrusion/Spheronisation.