ASSOCIATION OF ANXIETY, DEPRESSION, FOLATE AND VITAMIN B12 LEVELS WITH HYPEREMESIS GRAVIDARUM
Abstract

Author(s): Mehmet Yavuz Okyay EmelKiyak Caglayan, Ayse Yesim Gocmen, Yaprak Engin- Ust√ľn.

Objective: The aim of this study was to determine the relationship between Hyperemesis Gravidarum (HG) and serum folate/vitamin B12 levels and Beck score of anxiety/ depression. Methods: This is a c ase control study conducted at Obstetrics and Gynecology outpatient clinic between June 2013 - January 2014. The study group consisted of 80 with HG and 80 controls matched for age, gestational age. Age, education, occupation, family type, residence, status of pregnancy, body mass index (BMI) and smoking were questioned in all patients. Blood samples were drawn for complete blood count and calcium, magnesium, folic acid and vitamin B12 measurements. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were applied to all patients. Results: No significant difference was found in age and gestational week between patients and controls. HG was higher in patients at rural areas. BMI was found to be significantly lower in HG group (p<0.001). BAI and BDI scores were found to be significantly higher in patients with HG. Both folic acid and vitamin B12 levels were found to be lower in cases with HG (p<0.001). Conclusion: In our study, it was found that anxiety and depression were more common while serum folic acid and vitamin B12 levels were significantly lower in pregnant women with HG.