Author(s): Kumar Ajay, Jitendra Bajaj*, Neeraj Upmanyu

Liver is the most complex and important organs in the human body. A total loss of liver function leads to death within minutes. Liver is the largest gland in the body. It weighs about 1.5 kg (3 to 4 p ounds), lies immediately under the diaphragm, and occupies most of the right hypochondrium and part of the epigastrium. The common disorders of the liver include cirrhosis, viral hepatitis, alcoholic liver disease, hemochromatosis, and liver cancer. Liver transplantation is often the best option for either liver cancer or cirrhosis. There is an extreme shortage in the number of donor organs available, and there are restrictions on who can receive liver transplants. Due to these problems, alternatives are constantly being sought. Some of the primary areas of research involve gene therapy, xenotransplants, and bioartificial livers.