Journal of Harmonized Research in Pharmacy

AN OVERVIEW: FORMULATION AND EVALUATION FOR FAST DISSOLVING TABLETS

Abstract

Author(s): Md. Semimul Akhtar

Fast dissolving tablets emerge as one of the popular and widely accepted forms of dosage, particularly for pediatric patients due to incomplete muscle and nervous system development and a case of geri atric patients suffering from Parkinson's disorder or hand tremors. Few solid dosage forms such as capsules and tablets are currently facing problems such as swallowing difficulty (dysphasia), resulting in many incidences of non-compliance and in effectiveness of therapy. The most preferred route of administration of various drugs has drawbacks such as first-pass metabolism, psychiatric patients, bedridden patients and uncooperative patients is the oral dosage type and oral route. FDTs disintegrate or dissolve rapidly without the need for water in the saliva. Fast dissolving tablets are intended to dissolve within a few seconds (less than 60 seconds) in saliva surprisingly faster, and these are very fast-dissolving tablets. FDT formulations include super disintegrants to increase a tablet's level of disintegration in the buccal cavity. FDTs have advantages such as easy portability and development, reliable dosage, good chemical and physical stability, and a suitable option for patients with geriatric and pediatric diseases. FDTs have disintegrated rapidly, absorbing faster, improving in vitro drug release time, and enhancing the bioavailability of this property of drugs (form of dosage). The benefit of FDT formulations is the traditional tablet formulation and the liquid form of dosage. Many technologies have been developed for the manufacture of FDTs that are conventional or proprietary based on spray drying, cotton candy process, sublimation, melt granulation, direct drying lyophilization freezes, phase transition process, mass extrusion, etc. This review contains brief information on FDTs including the definition, benefits, needs or requirements of FDTs, salient features of FDTs, limitations, FDT development challenges, market formulations of fast dissolving tablets, etc