Journal of Harmonized Research in Pharmacy

ANTI-DIARRHOEAL ACTIVITY OF POLYCARPAEA CORYMBOSA (L.) LAM. WHOLE PLANT EXTRACTS (CARYOPHYLLACEAE)

Abstract

Author(s): Balamurugan K, Sakthidevi G, Mohan V.R

The objective of this study was to investigate the anti-diarrhoeal activity of whole plant of Polycarpaea corymbosa in rats. Anti-diarrhoeal effects of the ethanol extracts at 100, 200 and 400 mg/Kg were evaluated in rats using castor oil induced models. Results showed that the ethanol extract exhibited significant and dose dependent anti-diarrhoeal activity in the model used. A percentage diarrhoeal inhibition of extract at 400 mg/Kg was 75.63%. Diarrhoeal protection in the model used by the extract is dose dependent and the diarrhoeal inhibitory effects of the extract are comparable to loperamide. Therefore, a result of present study suggests that the ethanol extract of Polycarpaea corymbosa possesses anti-diarrhoeal activity.