DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC AND STRESS STUDIES METHOD FOR THE DETERMINATION OF VALACYCLOVIR HYDROCHLORIDE BOTH IN BULK AND MARKETED DOSAGE FORMULATIONS
Abstract
Author(s): Dr.K. Bhavyasri, M.V.S. Lavanya and Dr. Mogili. Sumakanth
A simple, accurate, precise UV spectrophotometric method was developed in pure and pharmaceutical formulations for Valacyclovir hydrochloride. It is a antiviral drug. Valacyclovir hydrochloride exhibiting maximum absorbance at 251 nm in distilled water and the method was validated for linearity, precision, sensitivity, and specificity. The drug obeyed linearity at concentration range of 2-32 µg/ml. The proposed method was validated statistically with significant high value of correlation coefficient 0.999. The percentage recovery value for Valacyclovir hydrochloride was in the range of 99.1 –99.7%. Therefore, the proposed method could be applied for the routine analysis of pharmaceutical dosage forms containing Valacyclovir hydrochloride. Forced degradation studies were also performed
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Citations : 147
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