Author(s): Khushboo Gupta, Sudeep Mandal , Pranjul Shrivastava, Poonam Sahu
In the biopharmaceutical classification system, albendazole is a class II drug, so its dissolutio n analysis is very difficult due to its low solubility and difficulty in estimating product in bulk. The present study deals with the design and validation of UV spectrophotometric methods to estimate albendazole in bulk form.Albendazole is a benzimidazole derivative that has an oral wide range of acti vity against parasites of human and animal helminths.The drug was obeying the law of the Beer and sh owing good correlation.It showed a peak absorption of sodium lauryl sulphate (SLS) at 229 nm in 0.1 N HCl.Linearity of 420µg / ml was observed.The method was used in the pure, tablet and suspension forms to analyze the drug. The regression line equation slope and intercept is 0.009 and 0.017 respecti vely. It was found that the coefficient of correlation was 0.9996.Restoration trials have confirmed the f indings of the study. The restoration has reached 97%. The method has been found to be simple, effect ive, fast, precise, detailed and reproducible and can be used in different dosage type and dissolution st udies for routine analysis of albendazole.