Author(s): Sunil Kumar Shah and Megha Agrawal
Difficulty in swallowing (Dysphasia) is a common problem of all age groups, especially the elderly and pediatrics because of physiological changes associated with these groups. In this view two form ulations Mucoadhesive Gel & Mucoadhesive Tablet was prepared to prolong contact time using three different Polymers. Gel formulation was selected as it is a semisolid dosage form. The application of bioadhesive gels provides an extended retention time, adequate drug penetration, as well as high efficacy and patient acceptability. In this work two Novel formulations Mucoadhesive Gel & tablets was prepared and evaluated using three different polymers (HPMC, Carbopol, Poloxamer) using an antileprotic drug Clofazimine.Gel was prepared by simple mixing method and tablets was prepared by Direct Compression Method using Rotary Tablet Punching Machine. The tablet weight was adjusted to 500mg and 75 tablets for each batch were prepared.