FORMULATION AND IN VITRO EVALUATION OF IMMEDIATE RELEASE SOFTGEL OF NAPROXEN SODIUM
Abstract
Author(s): Deepak Sarangi*, Suman Kumar Mekap, Sujit Kumar Patro, Rabinarayan Rana, Monalisa Mahapatra
Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutica l products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration and the belief that oral administration of the drug is well absorbed. One such area of research is design of Softgel technology. Softgel technology is one of the most attractive and promising approach for increasing oral bioavailability by means of increasing solubility of the poorly soluble drug. Naproxen Sodium is one of the most important Non-steroidal anti-inflammatory agents used in the treatment of acute to chronic pains, inflammation and it belongs to BCS class-II drug so as to increase its aqueous solubility for enhancing the bioavailability, it is formulated as a liquid filled soft gelatin capsules.
