Author(s): Ankita Mistry and Sonali Kapse-Mistry

Administration of pediatric medicines needs to be accurate and to ensure the correct dose, the administration device should be easy to use and acceptable. Continuous development and maturation of ped iatric organs involved in drug metabolism and clearance results in pharmacokinetic changes are focused. The review provides an overview of currently available innovative pediatric administration devices and highlights some of the challenges associated. Recent developments in oral transmucosal, parenteral, rectal, pulmonary and transdermal delivery to achieve better systemic drug levels in pediatric population are highlighted. A new nipple shield delivery system to deliver antiretroviral drug formulations to HIV infants to prevent mother-to-child HIV transmission during breastfeeding is discussed as a safe alternative. However the future of pediatric medicine is promising but challenges still remain.