Journal of Harmonized Research in Pharmacy

INVESTIGATION OF DYSLIPIDEMIAS ASSOCIATED WITH TYPE 2 DIABETES MELLITUS.

Abstract

Author(s): Musalula Sinkala, Trevor Kaile, Sandra Chileya, Clemence Marimo, Lydia Korolova, Geoffrey Kwenda, Gibson Sijumbila

Diabetes mellitus is a complex metabolic disease which affects carbohydrate, protein and lipid metabolism.In view of the significant effect on lipid metabolism we investigated the relationships betwee n type 2 diabetes mellitus and blood levels of triglycerides, cholesterol, high density lipoproteins (HDL) and low density lipoproteins (LDL). This was an analytical cross-sectional study where participants were adult patients with type 2 diabetes mellitus (cases) and without diabetes mellitus (controls). Diabetes mellitus patients had significantly higher levels of blood fatty acid synthase (FAS) and triglycerides than non diabetic controls. There was a weak insignificant positive correlation in blood levels of fatty acid synthase and triglycerides in both the patients and the controls. In addition the blood concentrations of cholesterol, HDL, and LDL were not significantly different between type 2 diabetes mellitus patients and non diabetic controls. Our conclusion was that type 2 diabetes mellitus patients had significantly higher levels of FAS and triglycerides than normal controls and that there was no significant positive correlation between FAS levels and triglyceride levels. In addition there was no significant difference in cholesterol metabolism between the two groups. Key words: Diabetes mellitus, Fatty acid synthase, Hypertriglyceridemia