SOLUBILITY ENHANCEMENT OF A POORLY AQUEOUS SOLUBLE DRUG USING SOLID DISPERSION TECHNIQUE
Abstract
Author(s): Rubendra Kurmi, Dinesh Kumar Mishra, Nitin Dubey, Dinesh Kumar Jain
The purpose of present work was to enhance the solubility and dissolution rate of Valsartan by solid dispersion technology employing various carriers such as sodium starch glycolate (SSG), Mannitol. Solid dispersions were prepared by physical mixing and solvent evaporation method. Various ratios of drug and carriers were used in the preparation in the ratio of 1:1, 1:1.5, 1:2, 1:2.5 and 1:3, 1:3.5. All the SD prepared was found to be fine free flowing powders and the drug content was uniform in all batches. The results of the disintegration test revealed that FT5 has faster disintegration within (5.3 min.)
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Citations : 147
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