Journal of Harmonized Research in Pharmacy

SYNTHESIS OF SOME NOVAL PARACETAMOL INCORPORATED THIAZOLIDINONE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY

Abstract

Author(s): Vivek Gupta*, A. Pandurangan

4-acetamidophenoxyacetylhydrazide is synthesized from paracetamol which on reaction with various aldehyde gives Schiff bases. Schiff bases treated with mercaptoaceticacid to produce thiazolidinenone derivatives. The entire synthesized compound characterized by physical and analytical data. The chemical structures of synthesized compound were confirmed by means of IR, 1HNMR and MS. Antimicrobial activity of synthesized compounds evaluated by cup-plate method. Synthesized compound showed good antimicrobial activity.